Food & Drink / Compounds / ADONA (4,8-dioxa-3H-perfluorononanoic acid)

ADONA (4,8-dioxa-3H-perfluorononanoic acid) in food: ingestion safety

Moderate risk

(People-specific data is limited; this page draws from human adult context.) Shorter half-life than legacy PFAS (~20 days in rats vs years for PFOA). Liver effects in animal studies at higher doses. Limited human epidemiological data. Marketed as safer alternative but persistence concerns remain.

What is adona (4,8-dioxa-3h-perfluorononanoic acid)?

The IUPAC name is 2,2,3-trifluoro-3-[1,1,2,2,3,3-hexafluoro-3-(trifluoromethoxy)propoxy]propanoic acid.

Also known as: RefChem:80841, Adona, 919005-14-4, 4,8-Dioxa-3H-perfluorononanoic acid.

IUPAC name
2,2,3-trifluoro-3-[1,1,2,2,3,3-hexafluoro-3-(trifluoromethoxy)propoxy]propanoic acid
CAS number
919005-14-4
Molecular formula
C7H2F12O4
Molecular weight
378.07 g/mol
SMILES
C(C(C(=O)O)(F)F)(OC(C(C(OC(F)(F)F)(F)F)(F)F)(F)F)F
PubChem CID
52915299

Risk for people

Moderate risk

Shorter half-life than legacy PFAS (~20 days in rats vs years for PFOA). Liver effects in animal studies at higher doses. Limited human epidemiological data. Marketed as safer alternative but persistence concerns remain.

Regulatory consensus

2 regulatory and scientific bodies have classified ADONA (4,8-dioxa-3H-perfluorononanoic acid). The classifications differ — that's the data.

AgencyYearClassificationNotes
German UBA——German Federal Environment Agency set precautionary guideline of 10 μg/L
ECHA——

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where you encounter adona (4,8-dioxa-3h-perfluorononanoic acid)

  • Drinking Water — Alz River downstream of Dyneon/3M Gendorf plant (Germany), Groundwater near fluoropolymer manufacturing
    Detected at ng/L levels in German drinking water
  • Industrial Process — Fluoropolymer (PTFE, PFA) manufacturing as processing aid
    Used as emulsifier in fluoropolymer production since ~2008

Safer alternatives

Lower-risk approaches that achieve a similar outcome to ADONA (4,8-dioxa-3H-perfluorononanoic acid):

  • Non-fluorinated dispersions for fluoropolymer manufacture
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 1.2-2×
  • Aqueous polymerization without fluorosurfactants
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 0.8-1.5×

Frequently asked questions

What products contain adona (4,8-dioxa-3h-perfluorononanoic acid)?

ADONA (4,8-dioxa-3H-perfluorononanoic acid) appears in: Alz River downstream of Dyneon/3M Gendorf plant (Germany) (drinking water); Groundwater near fluoropolymer manufacturing (drinking water); Fluoropolymer (PTFE, PFA) manufacturing as processing aid (industrial process).

See ADONA (4,8-dioxa-3H-perfluorononanoic acid) in the food app

Look up products containing adona (4,8-dioxa-3h-perfluorononanoic acid), compare to alternatives, and explore the full data record.

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Sources (1)
  1. — expert_curation

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →