Food & Drink / Compounds / N-MeFOSAA (N-methyl perfluorooctane sulfonamido acetic acid)

N-MeFOSAA (N-methyl perfluorooctane sulfonamido acetic acid) in food: ingestion safety

Elevated risk

(People-specific data is limited; this page draws from human adult context.) Long half-life. Transforms to PFOS (the most bioaccumulative legacy PFAS). Detected in >95% of Americans. Associated with immunotoxicity and hepatotoxicity as part of PFAS mixture exposure.

What is n-mefosaa (n-methyl perfluorooctane sulfonamido acetic acid)?

The IUPAC name is 2-[1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctylsulfonyl(methyl)amino]acetic acid.

Also known as: 2355-31-9, NMeFOSAA, 2-(N-Methylperfluorooctanesulfonamido)acetic acid, N-MeFOSAA.

IUPAC name
2-[1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctylsulfonyl(methyl)amino]acetic acid
CAS number
2355-31-9
Molecular formula
C11H6F17NO4S
Molecular weight
571.21 g/mol
SMILES
CN(CC(=O)O)S(=O)(=O)C(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F
PubChem CID
22286931

Risk for people

Elevated risk

Long half-life. Transforms to PFOS (the most bioaccumulative legacy PFAS). Detected in >95% of Americans. Associated with immunotoxicity and hepatotoxicity as part of PFAS mixture exposure.

Regulatory consensus

2 regulatory and scientific bodies have classified N-MeFOSAA (N-methyl perfluorooctane sulfonamido acetic acid). The classifications differ — that's the data.

AgencyYearClassificationNotes
EPA——
CDC/ATSDR——

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where you encounter n-mefosaa (n-methyl perfluorooctane sulfonamido acetic acid)

  • Human Biomonitoring — NHANES blood samples, General population serum
    One of 7 PFAS routinely detected in >95% of NHANES participants
  • Food Packaging — Historical 3M grease-proofing treatments, Legacy food-contact paper coatings
    Metabolite of N-MeFOSE-based paper treatments

Safer alternatives

Lower-risk approaches that achieve a similar outcome to N-MeFOSAA (N-methyl perfluorooctane sulfonamido acetic acid):

  • Non-fluorinated food packaging (wax, clay, silicone coatings)
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 1.2-2×

Frequently asked questions

What products contain n-mefosaa (n-methyl perfluorooctane sulfonamido acetic acid)?

N-MeFOSAA (N-methyl perfluorooctane sulfonamido acetic acid) appears in: NHANES blood samples (human biomonitoring); General population serum (human biomonitoring); Historical 3M grease-proofing treatments (food packaging); Legacy food-contact paper coatings (food packaging).

See N-MeFOSAA (N-methyl perfluorooctane sulfonamido acetic acid) in the food app

Look up products containing n-mefosaa (n-methyl perfluorooctane sulfonamido acetic acid), compare to alternatives, and explore the full data record.

Open in food View raw API data

Sources (1)
  1. — expert_curation

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →